Dr. Jenny Gandhi

WHAT IS
URETERIC OBSTRUCTION FROM TUMORS?

A blockage in the ureters, which are the tubes that transport urine from the kidneys to the bladder, brought on by a malignant growth is known as ureteric obstruction from tumors. This can occur when a tumor presses against the ureter from the outside (extrinsic) or when a tumor grows directly inside the ureter (intrinsic).

causes

prostate, bladder, rectal, colon
adjacent pelvic or retroperitoneal masses
Intraluminal obstruction
ureteral blockage
Tumor infiltration at the ureteral orifice
masses in the retroperitoneal
intrinsic or extrinsic tumors

symptoms

Blood in the urine
Pain in the lower back or side
Difficulty or pain during urination
Frequent urination or urinary incontinence
Recurrent urinary tract infections
Fatigue and unexplained weight loss
Urinary retention
Nausea or
Vomiting

if untreated?

Progressive kidney damage due to backup of urine (hydronephrosis) and increased pressure within the kidney.
Acute kidney injury or chronic kidney failure from prolonged obstruction.
Increased risk of urinary tract infections and potentially life-threatening urosepsis.
Severe pain and discomfort.
Electrolyte imbalances and metabolic complications.
Potential for irreversible loss of kidney function if obstruction persists.
Overall poor prognosis, especially as ureteric obstruction often occurs in advanced malignancies, with median survival ranging from a few months depending on cancer type and treatment options.

diagnosis

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Blood and Urine Tests
  • To assess kidney function (e.g., creatinine levels) and check for infection.
Ultrasound
  • Visualizes the kidneys and ureters to detect hydronephrosis and obstruction.
Computed Tomography (CT) Scan
  • Provides detailed cross-sectional images of kidneys, ureters, and surrounding tissues to locate and determine the cause of obstruction.
CT Urography / Magnetic Resonance Urography (MRU)
  • Advanced imaging techniques that provide detailed views of the urinary tract anatomy and obstructions.
Retrograde Pyelography
  • Dye is injected into the ureters via cystoscopy to pinpoint obstruction location and evaluate the ureter.
Renal Nuclear Scan
  • Uses radioactive tracers to assess kidney function and urinary drainage.
Cystoscopy
  • Allows direct visualization of the urethra, bladder, and ureteral openings with a camera.
Biopsy
  • In some cases, tissue samples from ureter or surrounding tumor may be taken for pathological diagnosis.

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